Effects of SK Channel Blockers on Atrial Myocytes Suggest SK Channel Heterogeneity
نویسندگان
چکیده
منابع مشابه
Antiarrhythmic principle of SK channel inhibition in atrial fibrillation.
The human heart beats more than two-billion times during an entire life (1) supplying the body with billions of litres of vital oxygenated blood, providing oxygen and energy to all cells and removing CO2. The heartbeat is therefore dependent on tightly regulated mechanisms to insure the maintenance of a regular heart rhythm, securing an appropriate blood circulation throughout life. These mecha...
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SK channels are upregulated in human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain poorly understood. We aim to test the hypotheses that activation of SK channels in ventricular myocytes requires Ca(2+) release from sarcoplasmic reticulum (SR) and that SK currents contribute to reducing triggered activity. SK2 c...
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A role for SK channels in synaptic plasticity has been very well-characterized. However, in the absence of simple genetic animal models, their role in behavioral memory remains elusive. Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory. Using two independent dSK a...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1585